Journal
BIOMATERIALS
Volume 112, Issue -, Pages 248-256Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.10.025
Keywords
Cell scaffold; Stem cell; Injectable hydrogel; Cell delivery; Phosphazene; Tissue regeneration
Funding
- Korea Institute of Science and Technology [2E26230]
- Korea National Research Foundation [2014M3A9B6034220]
- Ministry of Science, ICT & Future Planning, Republic of Korea [2E26230] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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An injectable hydrogel showing temperature-dependent chemical crosslinking was developed to combine injectabilities of physical hydrogels with dense structures of chemical hydrogels for applications in stem cell delivery-mediated tissue regeneration systems showing easy administration and maintenance of well-dispersed cells within the hydrogel. Hydrophobic methacryl groups were applied to thermosensitive poly(organophosphazenes) to induce temperature mediated hydrophobic interaction and chemical crosslinking. UV pretreated polymer solution showed chemical crosslinking not before injection only after injection into the body even it was already exposed to UV. As this injectable hydrogel showed small pore-sizes, it was guessed cell holding without any adhesive moieties were available and showed the potentials for a cell scaffold. In this study, temperature dependent chemical crosslinking and proliferation and differentiation of the encapsulated hMSCs into various tissues were observed in the hydrogels after injection. (C) 2016 Elsevier Ltd. All rights reserved.
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