Journal
BIOPHOTONICS AND IMMUNE RESPONSES XII
Volume 10065, Issue -, Pages -Publisher
SPIE-INT SOC OPTICAL ENGINEERING
DOI: 10.1117/12.2253802
Keywords
vascular targeted photodynamic therapy (V-PDT); blood vessel; dorsal skinfold window chamber; imaging
Funding
- National Natural Science Foundation of China [61520106015, 61635014]
- Fujian Provincial Natural Science Foundation [2014J07008]
- Program for Innovative Research Team in University [IRT-15R10]
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Vascular targeted photodynamic therapy (V-PDT) has been widely used for the prevention or treatment of vascular-related diseases, such as localized prostate cancer, wet age-related macular degeneration, port wine stains, esophageal varices and bleeding gastrointestinal mucosal lesions. In this study, the fundamental mechanisms of vascular responses during and after V-PDT will be introduced. Based on the V-PDT treatment of blood vessels in dorsal skinfold window chamber model, the structural and functional imaging, which including white light microscopy, laser speckle imaging, singlet oxygen luminescence imaging, and fluorescence imaging for evaluating vascular damage will be presented, respectively. The results indicate that vessel constriction and blood flow dynamics could be considered as the crucial biomarkers for quantitative evaluation of vascular damage. In addition, future perspectives of non-invasive optical imaging for evaluating vascular damage of V-PDT will be discussed.
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