Journal
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 52, Issue 3, Pages 314-326Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10409238.2017.1293606
Keywords
Transferrin; bacterial iron uptake; virulence factor; outer membrane protein; surface lipoprotein; TonB-dependent transporter
Categories
Funding
- NSERC [RGPIN 40197]
- CIHR [PJT-148804]
- Ontario Graduate Scholarship
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Transferrin is one of the sources of iron that is most readily available to colonizing and invading pathogens. In this review, we look at iron uptake by the bacterial transferrin receptor that is found in the families Neisseriaceae, Pasteurellaceae and Moraxellaceae. This bipartite receptor consists of the TonB-dependent transporter, TbpA, and the surface lipoprotein, TbpB. In the past three decades, major advancements have been made in our understanding of the mechanism through which the Tbps take up iron. We summarize these findings and discuss how they relate to the diversity and specificity of the transferrin receptor. We also outline several of the remaining unanswered questions about iron uptake via the bacterial transferrin receptor and suggest directions for future research.
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