4.8 Article

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

Related references

Note: Only part of the references are listed.
Article Genetics & Heredity

Integrated genomic characterization of IDH1-mutant glioma malignant progression

Hanwen Bai et al.

NATURE GENETICS (2016)

Article Biochemical Research Methods

Combenefit: an interactive platform for the analysis and visualization of drug combinations

Giovanni Y. Di Veroli et al.

BIOINFORMATICS (2016)

Article Oncology

Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer

Owen Clark et al.

CLINICAL CANCER RESEARCH (2016)

Article Biochemistry & Molecular Biology

Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity

Gouri Chatterjee et al.

NUCLEIC ACIDS RESEARCH (2016)

Editorial Material Multidisciplinary Sciences

Drugging DNA repair

Stephen P. Jackson et al.

SCIENCE (2016)

Review Hematology

IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives

Johanna Mondesir et al.

JOURNAL OF BLOOD MEDICINE (2016)

Review Pharmacology & Pharmacy

Synthetic Lethal Vulnerabilities of Cancer

Ferran Fece de la Cruz et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 (2015)

Article Oncology

Extreme Vulnerability of IDH1 Mutant Cancers to NAD plus Depletion

Kensuke Tateishi et al.

CANCER CELL (2015)

Article Cell Biology

Hypoxia Induces Production of L-2-Hydroxyglutarate

Andrew M. Intlekofer et al.

CELL METABOLISM (2015)

Review Chemistry, Medicinal

Drugging ATR: progress in the development of specific inhibitors for the treatment of cancer

Kevin M. Foote et al.

FUTURE MEDICINAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells

Katarina Smolkova et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2015)

Review Medicine, Research & Experimental

Targeting cancer with kinase inhibitors

Stefan Gross et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Biochemistry & Molecular Biology

Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia

Steven M. Chan et al.

NATURE MEDICINE (2015)

Article Endocrinology & Metabolism

The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo

Golam M. I. Chowdhury et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2014)

Article Medicine, Research & Experimental

MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis

Atsushi Terunuma et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Chemistry, Medicinal

KDM4B as a Target for Prostate Cancer: Structural Analysis and Selective Inhibition by a Novel Inhibitor

Chia-Han Chu et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

Caroline A. Lewis et al.

MOLECULAR CELL (2014)

Article Biochemistry & Molecular Biology

Open Comet: An automated tool for comet assay image analysis

Benjamin M. Gyori et al.

REDOX BIOLOGY (2014)

Review Cell Biology

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

Julie-Aurore Losman et al.

GENES & DEVELOPMENT (2013)

Article Biochemistry & Molecular Biology

Kdm4b Histone Demethylase Is a DNA Damage Response Protein and Confers a Survival Advantage following γ-Irradiation

Leah C. Young et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells

Ranjit S. Bindra et al.

NUCLEIC ACIDS RESEARCH (2013)

Article Genetics & Heredity

Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function

Ivana Murfuni et al.

PLOS GENETICS (2013)

Article Clinical Neurology

Enzymatic assay for quantitative analysis of (D)-2-hydroxyglutarate

Joerg Balss et al.

ACTA NEUROPATHOLOGICA (2012)

Article Biochemistry & Molecular Biology

RNF8-and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

Frederick A. Mallette et al.

EMBO JOURNAL (2012)

Article Multidisciplinary Sciences

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

Sevin Turcan et al.

NATURE (2012)

Article Genetics & Heredity

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

Michael Krauthammer et al.

NATURE GENETICS (2012)

Article Biochemistry & Molecular Biology

Hypoxia-Induced Epigenetic Regulation and Silencing of the BRCA1 Promoter

Yuhong Lu et al.

MOLECULAR AND CELLULAR BIOLOGY (2011)

Article Multidisciplinary Sciences

Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells

Anand G. Patel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Oncology

Plasma and cerebrospinal fluid pharmacokinetics of ABT-888 after oral administration in non-human primates

Jodi A. Muscal et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2010)

Correction Multidisciplinary Sciences

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate (vol 462, pg 739, 2010)

Lenny Dang et al.

NATURE (2010)

Article Medicine, General & Internal

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

Elaine R. Mardis et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Medicine, General & Internal

IDH1 and IDH2 Mutations in Gliomas

Hai Yan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Multidisciplinary Sciences

An integrated genomic analysis of human glioblastoma Multiforme

D. Williams Parsons et al.

SCIENCE (2008)

Article Oncology

Basal repression of BRCA1 by multiple E2Fs and pocket proteins at adjacent E2F sites

Ranjit S. Bindra et al.

CANCER BIOLOGY & THERAPY (2006)

Article Biochemical Research Methods

The comet assay: a method to measure DNA damage in individual cells

Peggy L. Olive et al.

NATURE PROTOCOLS (2006)

Article Multidisciplinary Sciences

Human fanconi anemia monoubiquitination pathway promotes homologous DNA repair

K Nakanishi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)