Journal
CHINESE CHEMICAL LETTERS
Volume 28, Issue 1, Pages 101-104Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2016.06.001
Keywords
2,3-Dihydroquinazolin-4(1H)-ones; alpha-Chymotrypsin; Cyclocondensation; Biocatalysis; 2-Aminobenzamides
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Funding
- National Natural Science Foundation of China [21262002, 21462001, 21465002]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT13054]
- Natural Science Foundation of Jiangxi [20142BAB203008]
- Science and Technology Foundation of the Jiangxi Education Department [KJLD12006, GJJ14466, KJLD14050]
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We discovered that a-chymotrypsin has a promiscuous ability to catalyze the cyclocondensation of aromatic and aliphatic aldehydes with 2-aminobenzamides to afford the corresponding 2,3dihydroquinazolin-4(1H)-ones successfully in high yields (90%-98%) under alcohol solvent. The catalytic activity of a-chymotrypsin was evaluated through investigating the temperature, the enzyme loading and the ratio of substrates in the enzyme-catalyzed reactions. The present method proves to be efficient and environmentally friendly in terms of short reaction time, high yield, green catalyst and the clean products obtained without further purification processes. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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