Journal
SCIENCE OF THE TOTAL ENVIRONMENT
Volume 580, Issue -, Pages 572-581Publisher
ELSEVIER
DOI: 10.1016/j.scitotenv.2016.11.214
Keywords
Black carbon; 1,4NQ-BC; IL-33; Lung
Categories
Funding
- Major Program of National Natural Science Foundation of China [21190051]
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Black carbon (BC) is a key component of atmospheric particles and has a significant effect on human health. BC can provide reactive sites and surfaces thus absorb quinones which were primarily generated from fossil fuel combustion and/or atmospheric photochemical conversions of PAHs. Oxidation could change the characteristics of BC and increase its toxicity. The comparison of lung damage in mice exposed to BC and 1,4-NQ-coated BC (1,4NQ-BC) particles is investigated in this study. Mice which were intratracheally instilled with particles have a higher expression of IL-113, IL-6 and IL-33 in bronchoalveolar lavage fluid (BALF).Also, the IL-6, IL-33 mRNA expression in the lung tissue of mice instilled with 1,4NQ-BC were higher than that of mice instilled with BC The pathology results showed that the lung tissue of mice instilled with 1,4NQ-BC particles have much more inflammatory cells infiltration than that of mice treated with BC It is believed that the MAPK and PI3K-AKT pathway might be involved in the 1,4NQ-BC particles caused lung damage. Results indicated that 1,4NQ-BC particles in the atmosphere may cause more damage to health. (C) 2016 Elsevier B.V. All rights reserved.
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