Journal
SCIENCE OF THE TOTAL ENVIRONMENT
Volume 595, Issue -, Pages 660-665Publisher
ELSEVIER
DOI: 10.1016/j.scitotenv.2017.04.036
Keywords
Bioavailability; Arsenic; Lead; Cadmium; Spiked-soil; Co-exposure
Categories
Funding
- Cooperative Research Centre for Contamination Assessment and Remediation of the Environment (CRC CARE) [3.1.07.11/12]
- Australian Government's Cooperative Research Centres Programme
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In this study, the influence of sample matrix on the relative bioavailability of arsenic (As), cadmium(Cd) and lead (Pb) was assessed following exposure of C57BL/6mice to spiked aged (12 years) soils. AIN93G mouse chow was amended with individual and tertiary As, Cd and Pb soil combinations which were administered to mice over a 9 day exposure period. Contaminant relative bioavailability was calculated by comparing As urinary excretion and Cd-kidney/Pb-liver accumulation to corresponding values for compounds used to derive the respective toxicity reference value. Strong linear dose-responses were observed for mice exposed to AIN93G mouse chow augmented with individually spiked soil with As, Cd and Pb. When mice were exposed to co-contaminants, As relative bioavailability (RBA) decreased similar to results from previous co-contaminant salt experiments presumably due to the influence of Cd on phosphate transport proteins, which are utilized for As absorption. However, a decrease in Cd-kidney and Pb-liver accumulation was also observed following co-co-exposure. It was postulated that this resulted from interactions with other (essential) metals (e.g. iron, aluminium, manganese, magnesium) within the soil matrix and their influence on absorption via divalent metal transporters. (C) 2017 Elsevier B.V. All rights reserved.
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