Journal
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Volume 56, Issue 1, Pages 5-18Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/cclm-2017-0120
Keywords
atherosclerosis; biomarkers; cardiovascular disease; inflammation; neutrophil gelatinase-associated lipocalin (NGAL)
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Neutrophil gelatinase-associated lipocalin (NGAL) is a promising diagnostic biomarker of early acute kidney injury. Increasing evidence suggests that NGAL may also be involved in inflammatory processes in cardiovascular disease. NGAL modulates the enzymatic activity of matrix metalloproteinase-9 (MMP-9), which is an important mediator of plaque instability in atherosclerosis. The complex formation between NGAL and MMP-9 therefore suggests that NGAL might play a role in progression of atherothrombotic disease. This review summarises current data on NGAL in atherosclerosis, acute myocardial infarction, and heart failure.
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