Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 5, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2017.00119
Keywords
cancer metabolism; nutrient sensing networks; transcription factors; histone acetylation; DNA and histone methylation; gene expression regulation
Categories
Funding
- CIBERONC
- Fundacion Vasca de Innovacion e Investigacion Sanitarias, BIOEF [BIO15/CA/052]
- Basque Department of Health [2016111109]
- Ramon y Cajal award
- Basque Department of Industry, Tourism and Trade (Etortek)
- department of education [IKERTALDE IT1106-16]
- BBVA foundation
- MINECO [SAF2016-79381-R]
- Severo Ochoa Excellence Accreditation [SEV-2016-0644]
- European Research Council [336343, PoC 754627]
- FEDER funds
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Cellular plasticity, or the ability of a cancer cell to adapt to changes in the microenvironment, is a major determinant of cell survival and functionality that require the coordination of transcriptional programs with signaling and metabolic pathways. In this scenario, these pathways sense and integrate nutrient signals for the induction of coordinated gene expression programs in cancer. This minireview focuses on recent advances that shed light on the bidirectional relationship between metabolism and gene transcription, and their biological outcomes in cancer. Specifically, we will discuss how metabolic changes occurring in cancer cells impact on gene expression, both at the level of the epigenetic landscape and transcription factor regulation.
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