Journal
SCIENCE CHINA-LIFE SCIENCES
Volume 60, Issue 11, Pages 1191-1196Publisher
SCIENCE PRESS
DOI: 10.1007/s11427-017-9128-3
Keywords
microbiota; liver; innate immune cells; liver inflammation
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Gut microbiota play an essential role in shaping immune cell responses. The liver was continuously exposed to metabolic products of intestinal commensal bacterial through portal vein and alteration of gut commensal bateria was always associated with increased risk of liver inflammation and autoimmune disease. Considered as a unique immunological organ, the liver is enriched with a large number of innate immune cells. Herein, we summarize the available literature of gut microbiota in shaping the response of hepatic innate immune cells including NKT cells, NK cells, gamma delta T cells and Kupffer cells during health and disease. Such knowledge might help to develop novel and innovative strategies for the prevention and therapy of innate immune cell-related liver disease.
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