Journal
AIDS
Volume 32, Issue 2, Pages 267-270Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0000000000001680
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Funding
- National Institutes of Health (NIH) [K01AI087369, R21AI073115, R01HD023412, U54 CA190146, K24HD054314]
- University of Washington (UW) Institute of Translational Health Sciences Multidisciplinary Clinical Research Training Program [TL1 TR 000422]
- Fogarty International Clinical Research Scholars Program from National Institutes of Health [5 R24 TW007988]
- UW Center for AIDS Research (CFAR)
- NIH [P30AI027757]
- UW Global Center for Integrated Health of Women, Adolescents and Children (Global WACh)
- Canadian Institutes for Health Research [136825]
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Polymorphisms in the Toll-like receptor 9 1635 locus have been associated with HIV-1 acquisition and progression. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) acquisition were compared between Kenyan HIV-exposed infants by 1635 genotype. Having one or more copies of the 1635A allele was associated with increased CMV acquisition in HIV-infected infants (42 vs. 11%, P=0.03) and increased risk of EBV acquisition in HIV-exposed uninfected infants (hazard ratio=4.2, P=0.02) compared with 1635GG. In addition, 1635A was associated with 0.4log(10) copies/ml lower median EBV levels in HIV-infected infants (P=0.03). These data suggest a potentially important role for this locus in primary herpesvirus infection.
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