Journal
SCIENCE CHINA-CHEMISTRY
Volume 61, Issue 1, Pages 113-117Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-017-9034-y
Keywords
OFBT; broad spectrum; antimicrobial activity
Categories
Funding
- National Natural Science Foundation of China [21533012, 21473220]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA09030306]
Ask authors/readers for more resources
Increasing multidrug-resistant (MDR) superbugs emerge worldwide causing a public health crisis. Consequently, it is urgent to find new antibiotics with efficient broad-spectrum antimicrobial activity. By virtue of versatility in molecular design, a new peptide-like cell membrane-broken molecule, oligo-(7,7'-bifluoren-benzo[c][1,2,5]thiadiazole) (OFBT) possessing a conjugated backbone and eight pendant guanidyl moieties was designed and synthesized. OFBT exhibits favorable broad-spectrum of antimicrobial activity to pathogens including Gram-negative and Gram-positive bacteria, and fungi with the minimum inhibitory concentration (MIC) below 3.0 mu M. Moreover, OFBT exhibits high selectivity for pathogens over human cells to make it a promising broad spectrum antimicrobial agent.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available