Journal
AAPS PHARMSCITECH
Volume 19, Issue 1, Pages 27-35Publisher
SPRINGER
DOI: 10.1208/s12249-017-0865-3
Keywords
crystallization; transdermal patches; precipitation; instability; physical
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The transdermal patch formulation has many advantages, including noninvasiveness, an ability to bypass the first-pass metabolism, low dosage requirements, and prolonged drug delivery. However, the instability of solid-state drugs is one of the most critical problems observed in transdermal patch products. Therefore, a well-characterized approach for counteracting stability problems in solid-state drugs is crucial for improving the performance of transdermal patch products. This review provides insight into the solid-state stability of drugs associated with transdermal patch products and offers a comprehensive update on the various approaches being used for improving the stability of the active pharmaceutical ingredients currently being used.
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