Journal
SCIENCE
Volume 356, Issue 6342, Pages 1064-1068Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aal5005
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Funding
- U.S. Air Force Office of Scientific Research [FA9550-15-1-0192]
- Planning and Budget Committee of the Israeli Council for Higher Education
- Netherlands Organization for Scientific Research (Veni program) [722.015.005]
- Materials Research Science and Engineering Center program of the National Science Foundation (NSF) [DMR-0820341, DMR-1420073]
- NSF [CHE-1346572]
- U.S. DOE [DE-AC02-06CH11357]
- City University of New York
- NSF
- National Institute on Minority Health and Health Disparities (NIMHD) of the NIH
- Engineering and Physical Sciences Research Council [EP/K000586/1]
- EPSRC [EP/K000586/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K000586/1] Funding Source: researchfish
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1346572] Funding Source: National Science Foundation
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Melanins are a family of heterogeneous polymeric pigments that provide ultraviolet (UV) light protection, structural support, coloration, and free radical scavenging. Formed by oxidative oligomerization of catecholic small molecules, the physical properties of melanins are influenced by covalent and noncovalent disorder. We report the use of tyrosine-containing tripeptides as tunable precursors for polymeric pigments. In these structures, phenols are presented in a (supra-)molecular context dictated by the positions of the amino acids in the peptide sequence. Oxidative polymerization can be tuned in a sequence-dependent manner, resulting in peptide sequence-encoded properties such as UV absorbance, morphology, coloration, and electrochemical properties over a considerable range. Short peptides have low barriers to application and can be easily scaled, suggesting near-term applications in cosmetics and biomedicine.
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