Journal
SCIENCE
Volume 355, Issue 6328, Pages 962-965Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aai8898
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Funding
- Chinese Academy of Sciences [XDA08010201-1]
- Ministry of Agriculture of China [2014ZX08009-003-001]
- National Natural Science Foundation of China [31330061]
- Ministry of Science and Technology of China [2016YFD0100600]
- Science and Technology Commission of Shanghai Municipality [201404040301037]
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Crop breeding aims to balance disease resistance with yield; however, single resistance (R) genes can lead to resistance breakdown, and R gene pyramiding may affect growth fitness. Here we report that the rice Pigm locus contains a cluster of genes encoding nucleotide-binding leucine-rich repeat (NLR) receptors that confer durable resistance to the fungus Magnaporthe oryzae without yield penalty. Among these NLR receptors, PigmR confers broad-spectrum resistance, whereas PigmS competitively attenuates PigmR homodimerization to suppress resistance. PigmS expression, and thus PigmR-mediated resistance, are subjected to tight epigenetic regulation. PigmS increases seed production to counteract the yield cost induced by PigmR. Therefore, our study reveals a mechanism balancing high disease resistance and yield through epigenetic regulation of paired antagonistic NLR receptors, providing a tool to develop elite crop varieties.
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