Journal
SCIENCE
Volume 355, Issue 6329, Pages 1076-1080Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aah4563
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Funding
- INFRAVEC, its Bioinformatics Access Facility and Illumina sequencing
- Sven and Lilly Lawski Foundation
- Linnaeus Initiative Insect chemical ecology, ethology and evolution, IC-E3 Formas, SLU
- Knut and Alice Wallenberg Foundation [KAW 2012.0058]
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Malaria infection renders humans more attractive to Anopheles gambiae sensu lato mosquitoes than uninfected people. The mechanisms remain unknown. We found that an isoprenoid precursor produced by Plasmodium falciparum, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), affects A. gambiae s. l. blood meal seeking and feeding behaviors as well as susceptibility to infection. HMBPP acts indirectly by triggering human red blood cells to increase the release of CO2, aldehydes, and monoterpenes, which together enhance vector attraction and stimulate vector feeding. When offered in a blood meal, HMBPP modulates neural, antimalarial, and oogenic gene transcription without affecting mosquito survival or fecundity; in a P. falciparum-infected blood meal, sporogony is increased.
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