Journal
SCIENCE
Volume 357, Issue 6346, Pages 46-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aal3753
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Funding
- Swedish Research Council
- Bertil Hallsten Research Foundation
- ERC Consolidator grant
- Ake Wiberg Foundation
- Swedish Cancer Foundation
- Soderberg Foundation
- ERC advanced grant (PainCells)
- NSF CAREER award [NSF-14-532]
- National Heart, Lung, and Blood Institute [NIH 1R01HL131768]
- Russian Science Foundation (RSF) [16-15-10273]
- VR [2015-03387]
- StratNeuro
- Russian Foundation for Basic Research [16-04-01243]
- RSF [17-74-20037]
- VR Foundation
- KI Foundation
- Ragnar Soderberg Foundation
- Wallenberg Foundation
- VR International Postdoc Fellowship
- Stipend for Young Scientists [Ccoproduct -2890.2016.4]
- Russian Science Foundation [16-15-10273] Funding Source: Russian Science Foundation
- Swedish Research Council [2015-03387] Funding Source: Swedish Research Council
- Direct For Biological Sciences
- Div Of Biological Infrastructure [1452964] Funding Source: National Science Foundation
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Adrenaline is a fundamental circulating hormone for bodily responses to internal and external stressors. Chromaffin cells of the adrenal medulla (AM) represent the main neuroendocrine adrenergic component and are believed to differentiate from neural crest cells. We demonstrate that large numbers of chromaffin cells arise from peripheral glial stem cells, termed Schwann cell precursors (SCPs). SCPs migrate along the visceral motor nerve to the vicinity of the forming adrenal gland, where they detach from the nerve and form postsynaptic neuroendocrine chromaffin cells. An intricate molecular logic drives two sequential phases of gene expression, one unique for a distinct transient cellular state and another for cell type specification. Subsequently, these programs down-regulate SCP-gene and up-regulate chromaffin cell-gene networks. The AM forms through limited cell expansion and requires the recruitment of numerous SCPs. Thus, peripheral nerves serve as a stem cell niche for neuroendocrine system development.
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