Journal
SCIENCE
Volume 356, Issue 6335, Pages 316-319Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aah6412
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Funding
- European Research Council [616434]
- Spanish Ministry of Economy and Competitiveness [BFU2011-26206, SEV-2012-0208, BFU2015-70581]
- AXA Research Fund
- Bettencourt Schueller Foundation
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR)
- Framework Programme 7 project 4DCellFate [277899]
- European Molecular Biology Laboratory-Center for Genomic Regulation (CRG) Systems Biology Program
- la Caixa Fellowship
- FI AGAUR Ph.D. fellowship
- ICREA Funding Source: Custom
- European Research Council (ERC) [616434] Funding Source: European Research Council (ERC)
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The environment experienced by an animal can sometimes influence gene expression for one or a few subsequent generations. Here, we report the observation that a temperature-induced change in expression from a Caenorhabditis elegans heterochromatic gene array can endure for at least 14 generations. Inheritance is primarily in cis with the locus, occurs through both oocytes and sperm, and is associated with altered trimethylation of histone H3 lysine 9 (H3K9me3) before the onset of zygotic transcription. Expression profiling reveals that temperature-induced expression from endogenous repressed repeats can also be inherited for multiple generations. Long-lasting epigenetic memory of environmental change is therefore possible in this animal.
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