Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 102, Issue 2, Pages 689-702Publisher
SPRINGER
DOI: 10.1007/s00253-017-8648-z
Keywords
Amycolatopsis mediterranei S699; Pentangular polyphenols; Topoisomerase II alpha inhibitor; min-PKS
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Funding
- National Natural Science Foundation of China [81373304, 81673317]
- Science Foundation of Two Sides of Strait [U1405223]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_17R68]
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Ten new pentangular polyphenols, namely amexanthomycins A-J (1-10) were isolated from the strain Amycolatopsis mediterranei S699a dagger rifA constructed by deleting the polyketide synthase genes responsible for the biosynthesis of rifamycins. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data and high-resolution ESIMS. Amexanthomycins A-C (1-3) showed inhibitory activity against human DNA topoisomerases.
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