Journal
FRONTIERS IN NUTRITION
Volume 4, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnut.2017.00075
Keywords
polyphenols; tomato; metabolic engineering; microbiota; inflammatory bowel disease
Categories
Funding
- Italian Ministry of Health [GR-2011-02347991]
- Apulia Region project NATURE-XUANRO4.
- European Union FP6 FLORA project [FOOD-CT-01730]
- European Union FP7 ATHENA collaborative project [245121]
- Institute Strategic Program Understanding and Exploiting Plant and Microbial Secondary Metabolism from the BBSRC [BB/J004596/1]
- EU H project [679796]
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000PR9790, BBS/E/J/000PR9799, BB/M004864/1, BBS/E/J/000CA424, BB/L014130/1, BBS/E/J/0000A231, BB/N005023/1, BBS/E/J/00000153] Funding Source: researchfish
- BBSRC [BB/N005023/1, BBS/E/J/000PR9790, BBS/E/J/000CA424, BB/L014130/1, BB/M004864/1] Funding Source: UKRI
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Dietary polyphenols are associated with a wide range of health benefits, protecting against chronic diseases and promoting healthy aging. Dietary polyphenols offer a complementary approach to the treatment of inflammatory bowel diseases (IBDs), a group of common chronic intestinal inflammation syndromes for which there is no cure. Tomato is widely consumed but its content of polyphenols is low. We developed a tomato variety, Bronze, enriched in three distinct classes of polyphenols: flavonols, anthocyanins, and stilbenoids. Using Bronze tomatoes as a dietary supplement as well as Indigo (high anthocyanins and flavonols), ResTom (high stilbenoids) and wild-type tomatoes, we examined the effects of the different polyphenols on the host gut microbiota, inflammatory responses, and the symptoms of chronic IBD, in a mouse model. Bronze tomatoes significantly impacted the symptoms of IBD. A similar result was observed using diets supplemented with red grape skin containing flavonols, anthocyanins, and stilbenoids, suggesting that effective protection is provided by different classes of polyphenols acting synergistically.
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