Journal
NATURE
Volume 553, Issue 7689, Pages 418-426Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature25022
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Funding
- Sir Henry Dale fellowship from the Wellcome Trust (WT)/Royal Society
- WT
- CRUK
- Bloodwise
- MRC
- BBSRC
- NIH-NIDDK
- BBSRC [BB/P002293/1] Funding Source: UKRI
- MRC [MR/M008975/1, G0900951, MC_PC_16040] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/P002293/1] Funding Source: researchfish
- Cancer Research UK [21762] Funding Source: researchfish
- Medical Research Council [MR/M008975/1, MC_PC_12009, G0900951] Funding Source: researchfish
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The development of mature blood cells from haematopoietic stem cells has long served as a model for stem-cell research, with the haematopoietic differentiation tree being widely used as a model for the maintenance of hierarchically organized tissues. Recent results and new technologies have challenged the demarcations between stem and progenitor cell populations, the timing of cell-fate choices and the contribution of stem and multipotent progenitor cells to the maintenance of steady-state blood production. These evolving views of haematopoiesis have broad implications for our understanding of the functions of adult stem cells, as well as the development of new therapies for malignant and nonmalignant haematopoietic diseases.
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