Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 28, Issue 4, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201705380
Keywords
dendritic silica; fluorescence detection; immunoassays; nanoassembly; quantum dots
Categories
Funding
- National Natural Science Foundation of China [21501191, 21405139, 51672248, 21672254]
- Shenzhen Sciences & Technology Innovation Council [JCYJ20150630114942307]
- Public Project of Zhejiang Province [2017C33172, 2017C31049]
Ask authors/readers for more resources
Creating secondary nanostructures from fundamental building blocks with simultaneous high loading capacity and well-controlled size/uniformity, is highly desired for nanoscale synergism and integration of functional units. Here a novel strategy is reported for hydrophobic quantum dots (QDs) assembley with porous templates, to form pitaya-type fluorescent silica colloids with densely packed and intact QDs throughout the silica matrix. The mercapto-terminated dendritic silica spheres with highly accessible centralradial pores and metal-affinity interior surface, are adopted as a powerful absorbent host for direct immobilization of QDs from organic phase with high loading capacity. The alkylsilane mediated silica encapsulation prevents QDs' optical degradation induced by ligand exchange and favors the homogeneous silica shell formation. These multiple QD embedded silica spheres exhibit good compatibility for different colored QDs with well-preserved fluorescence, high colloidal/optical stability, and versatile surface functionality. It is demonstrated that after integration with a lateral flow strip platform, these silica colloids provide an ultrasensitive, specific, and robust immunoassay for C-reaction protein in clinical samples as promising fluorescent reporters.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available