Kruppel-Like Factors Crippling and Uncrippling Metabolic Pathways

Kruppel-like factors (KLFs) are deoxyribonucleic acid-binding transcriptional factors that regulate various pathways that control metabolism and other cellular mechanisms. Various KLF isoforms have been associated with cellular, organ, or systemic metabolism. Altered expression or activation of KLFs has been linked to metabolic abnormalities, such as obesity and diabetes, as well as with heart failure. This review article summarizes the metabolic functions of KLFs, as well as the networks of different KLF isoforms that jointly regulate metabolism in health and disease. (C) 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.