Journal
CANCER RESEARCH
Volume 78, Issue 3, Pages 798-808Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-17-2880
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Funding
- Nanjing Science and Technology Development Foundation [201605031]
- Jiangsu Provincial Medical Youth Talent Award [QNRC2016054]
- Nanjing Medical Science and Technology Development Foundation-Youth Program [ZDX16008]
- Natural Science Foundation of Jiangsu Province [BK20170134]
- National Cancer Institute of the NIH [DP2CA174508]
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Extracellular nanovesicles (ENV) released by many cells contain lipids, proteins, and nucleic acids that contribute to intercellular communication. ENVs have emerged as biomarkers and therapeutic targets but they have also been explored as drug delivery vehicles. However, for the latter application, clinical translation has been limited by low yield and inadequate targeting effects. ENV vectors with desired targeting properties can be produced from parental cells engineered to express membrane-bound targeting ligands, or they can be generated by fusion with targeting liposomes; however, neither approach has met clinical requirements. In this study, we demonstrate that mechanical extrusion of approximately 107 cells grafted with lipidated ligands can generate cancer cell-targeting ENV and can be prepared in approximately 1 hour. This rapid and economic approach could pave the way for clinical implementation in the future. Significance: A new and rapid method for production of drug-targeting nanovesicles has implications for cancer treatment by chimeric antigen receptor T cells and other therapies. (C) 2017 AACR.
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