Journal
SCHIZOPHRENIA RESEARCH
Volume 189, Issue -, Pages 104-110Publisher
ELSEVIER
DOI: 10.1016/j.schres.2017.01.044
Keywords
DLPFC; Schizophrenia; Theta-gamma coupling; Working memory
Categories
Funding
- Brain and Behavior Young Investigator Grant
- Brain Canada
- Brain and Behavior Research Foundation [17826]
- Canada Foundation for Innovation
- Canada Research Chair
- Canadian Institutes of Health Research (CIHR) [244041]
- Ontario Ministry of Health and Long-Term Care
- Ontario Ministry of Research and Innovation [25861]
- US National Institute of Health (NIH)
- W. Garfield Weston Foundation
- Pfizer [A3051123/A3051148]
- NIH [2U01-DA-020830, R34MH101365]
- CIHR [MOP115145, MOP-136801]
- Temerty Family through the Centre for Addiction and Mental Health (CAMH) Foundation
- Campbell Research Institute
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Background: Working memory deficits represent a core feature of schizophrenia. These deficits have been associated with dysfunctional dorsolateral prefrontal cortex (DLPFC) cortical oscillations. Theta-gamma coupling describes the modulation of gamma oscillations by theta phasic activity that has been directly associated with the ordering of information during working memory performance. Evaluating theta-gamma coupling may provide greater insight into the neural mechanisms mediating working memory deficits in this disorder. Methods: Thirty-eight patients diagnosed with schizophrenia or schizoaffective disorder and 38 healthy controls performed the verbal N-Back task administered at 4 levels, while EEG was recorded. Theta (4-7 Hz)-gamma(30-50 Hz) coupling was calculated for target and non-target correct trials for each working memory load. The relationship between theta-gamma coupling and accuracy was determined. Results: Theta-gamma coupling was significantly and selectively impaired during correct responses to target letters among schizophrenia patients compared to healthy controls. A significant and positive relationship was found between theta-gamma coupling and 3-Back accuracy in controls, while this relationship was not observed in patients. Conclusions: These findings suggest that impaired theta-gamma coupling contribute to working memory dysfunction in schizophrenia. Future work is needed to evaluate the predictive utility of theta-gamma coupling as a neurophysiological marker for functional outcomes in this disorder. (C) 2017 Elsevier B.V. All rights reserved.
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