Journal
EMERGING INFECTIOUS DISEASES
Volume 24, Issue 2, Pages 242-248Publisher
CENTERS DISEASE CONTROL
DOI: 10.3201/eid2402.171074
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Funding
- BMBF [03ZZ0802H]
- German Center for Infection Research [TTU 08.807, 8037808809]
- European Regional Development Fund within the EurHealth-1Health project [EU/INTERREG VA-681377]
- [01KI1727A]
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During cefoxitin-based nasal screening, phenotypically categorized methicillin-resistant Staphylococcus aureus (MRSA) was isolated and tested negative for the presence of the mecA and mecC genes as well as for the SCCmec-orfX junction region. The isolate was found to carry a mecB gene previously described for Macrococcus caseolyticus but not for staphylococcal species. The gene is flanked by beta-lactam regulatory genes similar to mecR, mecI, and blaZ and is part of an 84.6-kb multidrug-resistance plasmid that harbors genes encoding additional resistances to aminoglycosides (aacA-aphD, aphA, and aadK) as well as macrolides (ermB) and tetracyclines (tetS). This further plasmid-borne beta-lactam resistance mechanism harbors the putative risk of acceleration or reacceleration of MRSA spread, resulting in broad ineffectiveness of beta-lactams as a main therapeutic application against staphylococcal infections.
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