Journal
SCHIZOPHRENIA RESEARCH
Volume 181, Issue -, Pages 83-85Publisher
ELSEVIER
DOI: 10.1016/j.schres.2016.09.011
Keywords
ICA; Polygenic risk score; Schizophrenia; PGC
Categories
Funding
- National Institutes of Health [P20GM103472, R01EB005846, 1R01EB006841, 1R01MH094524-01A1]
- NSF EPSCoR grant [1539067]
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Schizophrenia is a psychiatric disorder with high heritability. Recent genome-wide association studies have provided a list of risk loci reliably derived from unprecedentedly large samples. However, further delineation of the diagnosis-associated susceptibility variants is needed to better characterize the genetic architecture given the disease's complex nature. In this sense, a data-driven approach might hold promise for identifying functionally related clusters of genetic variants that might not be captured by hypothesis-based models. In the current study, independent component analysis (ICA) was applied to the Psychiatric Genomics Consortium's schizophrenia-related single nucleotide polymorphisms (SNPs) in 104 schizophrenia patients and 142 healthy controls of European Ancestry. We found that, for 13 out of 16 extracted independent components, the associated loadings correlated highly (r > 0.5) with the polygenic risk scores for SZ of the corresponding SNPs. These correlationswere likely not inflated by the linkage disequilibriumstructure (permutation p < 0.001). In brief, we demonstrate an example of ICA analysis on SNP data yielding functionally meaningful clusters, which motivates further application of data-driven approaches as a complimentary tool for hypothesis-based methods to enrich our knowledge on the genetic basis of complex disorders. (C) 2016 Elsevier B.V. All rights reserved.
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