Journal
THERAPEUTIC DELIVERY
Volume 9, Issue 2, Pages 137-153Publisher
FUTURE SCI LTD
DOI: 10.4155/tde-2017-0088
Keywords
anterior segment; nanoparticles; noninvasive; topical
Categories
Funding
- National Eye Institute [1R01EY022120-01A1]
- National Institute of General Medical Sciences [P20GM104932]
- National Institutes of Health
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Over the past decade, there has been a rise in the number of clinical cases of moderate to severe anterior segment ocular diseases. Conventional topical ophthalmic formulations have several limitations - to address which, novel drug-delivery systems are needed. Additionally, formidable physiological barriers limit ocular bioavailability through the topical route of application. During the last decade, various nano-scaled ocular drug-delivery strategies have been reported. Some of these exploratory, topical, noninvasive approaches have shown promise in improving penetration into the anterior segment tissues of the eye. In this article, we review the available literature with respect to the safety, efficiency and effectiveness of these nano systems.
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