Journal
CURRENT OPINION IN ANESTHESIOLOGY
Volume 31, Issue 1, Pages 55-60Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ACO.0000000000000549
Keywords
ascorbic acid; resuscitation; sepsis; supplements; vitamin C
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Funding
- National Institutes of Health (NIH) [K23DA040923]
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Purpose of review This narrative review summarizes recent insights into the role of vitamin C in sepsis. Recent findings Septic shock remains a major source of morbidity and mortality in critically ill patients. Although many nutritional supplements have previously been tested unsuccessfully, vitamins are still being explored as a therapeutic option in septic patients. In particular, vitamin C-containing regimens as adjunctive therapy in sepsis have received much attention. Summary In-vitro evidence supports a critical role for vitamin C in cellular mechanisms relevant to the pathophysiology of sepsis. However, whether this justifies therapeutic use of vitamin C in septic patients remains uncertain.
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