Journal
BIOMETALS
Volume 31, Issue 1, Pages 123-129Publisher
SPRINGER
DOI: 10.1007/s10534-017-0073-3
Keywords
Lactoferrin; Neutrophil gelatinase-associated lipocalin; Meconium; Fetus
Categories
Funding
- National Centre for Science [DEC-2011/01/B/NZ7/00648]
Ask authors/readers for more resources
Neutrophil gelatinase-associated lipocalin (NGAL) and lactoferrin (Lf) are among the key components of the innate immune system due to their ability to bind iron with high affinity and thus control inflammation. The aim of this study was to test the use of NGAL and LF measurements in meconium for the assessment of the intrauterine homeostasis. NGAL and Lf concentrations were measured using ELISA kits in all serial meconium portions (n = 81) collected from 20 healthy neonates. Mean +/- SD meconium concentration of Lf was 45.07 +/- 78.53 mu g/g and more than 1000-fold higher compared with that of NGAL at 1.93 +/- 2.46 ng/g. The correlation between the two proteins (r = 0.83, p < 0.0001) was found only for portions with Lf concentrations > 25 mu g/g. High variability of NGAL and Lf concentrations in meconium and their correlations prove their key role as biomarkers of the fetal condition in utero. NGAL and Lf measured in meconium are candidate biomarkers for fetal iron status.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available