Journal
CLINICAL INFECTIOUS DISEASES
Volume 66, Issue 3, Pages 460-463Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/cix934
Keywords
carbapenem resistance; healthcare-associated infection; genomic epidemiology; Enterobacter cloacae; CRE
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Funding
- University of Michigan Medical School Host Microbiome Initiative
- National Institutes of Health [T32-GM113900]
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A genomic epidemiologic investigation of a putative carbapenem-resistant Enterobacter cloacae outbreak revealed few plausible instances of nosocomial transmission, highlighting instead the frequent importation of E. cloacae into our hospital. Searching for genetic determinants of carbapenem resistance demonstrated that most resistance is due to convergent mutations in phylogenetically diverse E. cloacae.
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