Journal
CHEMICAL REVIEWS
Volume 118, Issue 3, Pages 377-461Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.7b00205
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Funding
- ATIP Avenir grant
- Investments for the future Programme IdEx Bordeaux [ANR-10-IDEX-03-02]
- Comision Sectorial de Investigacion Cientifica (CSIC), Universidad de la Republica, Uruguay
- NIH [HL58984, GM112455]
- ATIP Avenir grant
- Investments for the future Programme IdEx Bordeaux [ANR-10-IDEX-03-02]
- Comision Sectorial de Investigacion Cientifica (CSIC), Universidad de la Republica, Uruguay
- NIH [HL58984, GM112455]
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Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for understanding the physiological and pharmacological effects of H2S. Due to the inherent instability of persulfides, their chemistry is understudied. In this review, we discuss the biologically relevant chemistry of H2S and the enzymatic routes for its production and oxidation. We cover the chemical biology of persulfides and the chemical probes for detecting them. We conclude by discussing the roles ascribed to protein persulfidation in cell signaling pathways.
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