Journal
RUSSIAN JOURNAL OF GENETICS
Volume 53, Issue 9, Pages 972-981Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1022795417080063
Keywords
soluble epoxide hydrolase; arterial hypertension; RNA-Seq; real-time PCR; ISIAH rat strain
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Funding
- Russian Science Foundation [14-15-00118]
- Federal Research Fund [0324-2016-0002]
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Using ISIAH rat strain, an animal model for stress-sensitive form of arterial hypertension, a comparison of the brain stem, hypothalamus, adrenal gland, and kidney transcriptomes for identification of the key genes involved in the development of the stress-sensitive form of arterial hypertension was conducted. Our studies revealed Ephx2 gene encoding soluble epoxide hydrolase (sEH), whose transcription level was significantly higher in all the examined organs. On the basis of other studies and our previous investigations, we concluded the necessity of further studies of Ephx2 gene and an encoded sEH protein as a potential target for pharmacological treatment of stress-sensitive arterial hypertension.
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