Journal
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
Volume 87, Issue 11, Pages 2654-2663Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1070363217110214
Keywords
Schiff base; morpholine; DNA interaction; DNA cleavage; antioxidant; antimicrobial
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Funding
- Department of Science and Technology (DST) - Science and Engineering Research Board (SERB), Government of India, New Delhi [SR/FT/CS-117/2011]
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A new series of metal(II) complexes 1-5 of the type [M(L)(AcO)(2)H2O], where L is a bidentate ligand, 2-(3-morpholinopropylimino)methylphenol and M is Mn(II) (1), Co(II) (2), Ni(II) (3), Cu(II) (4), and Zn(II) (5), have been isolated and characterized by physico-chemical and spectral methods. Spectroscopic data supported the square pyramidal geometry around the central metal ion in the complexes 1-5. Absorption spectra and viscometric data indicated that the complexes 1-5 interacted with calf thymus (CT) DNA via intercalative strategy. Cleavage activities of complexes 1-5 with CT DNA were analyzed by gelelectrophoretic method. The in vitro antioxidant activity of complexes 1-5 was tested using the DPPH assay. The complexes 1-5 have been tested for antimicrobial activity against some pathogenic bacterial and fungal species by the agar well diffusion method.
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