Journal
CALCIFIED TISSUE INTERNATIONAL
Volume 102, Issue 2, Pages 174-195Publisher
SPRINGER
DOI: 10.1007/s00223-017-0372-2
Keywords
Osteosarcoma; Ewing sarcoma; Chondrosarcoma; Giant cell tumour of bone; Tumour microenvironment; Immunotherapy; Clinical trials
Categories
Funding
- Bone Cancer Research Trust [144681]
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Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma, Ewing sarcoma and chondrosarcoma each subdivided in diverse histological entities. They are clinically characterised by a relatively high morbidity and mortality, especially in children and adolescents. Although these tumours are histologically, molecularly and genetically heterogeneous, they share a common involvement of the local microenvironment in their pathogenesis. This review gives a brief overview of their specificities and summarises the main therapeutic advances in the field of bone sarcoma.
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