Journal
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
Volume 43, Issue 1, Pages 91-97Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162016060121
Keywords
sea anemone; Kunitz-type protease inhibitors; antihistamine activity
Funding
- Russian Science Foundation [14-25-00037]
- Russian Science Foundation [14-25-00037] Funding Source: Russian Science Foundation
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Antihistamine activity of recombinant peptides, Kunitz- type serine protease inhibitors of the sea anemone Heteractis crispa, was studied. It was shown that the peptides rHCGS1.19 and rHCGS1.36 at a concentration 10 mu Minhibit an increase in the calcium ion concentration in macrophages elicited by histamine at 62.2 and 84.0%, respectively. The anti-inflammatory effect can be seen as the result of mediated reactions between peptides and proteases involved in these processes, as with the histamine H-1-type receptor blocking.
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