Kunitz-Type Peptides of the Sea Anemone Heteractis crispa: Potential Anti-Inflammatory Compounds

Antihistamine activity of recombinant peptides, Kunitz- type serine protease inhibitors of the sea anemone Heteractis crispa, was studied. It was shown that the peptides rHCGS1.19 and rHCGS1.36 at a concentration 10 mu Minhibit an increase in the calcium ion concentration in macrophages elicited by histamine at 62.2 and 84.0%, respectively. The anti-inflammatory effect can be seen as the result of mediated reactions between peptides and proteases involved in these processes, as with the histamine H-1-type receptor blocking.