Journal
ENVIRONMENTAL SCIENCE & TECHNOLOGY
Volume 49, Issue 21, Pages 12975-12983Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.est.5b03294
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Funding
- Fundamental Research Funds for the Central Universities [2662015PY036]
- Huazhong Agricultural University Scientific & Technological Self-innovation Foundation [2014RC001]
- Environmental Monitoring Funds of Jiangsu Province [1405]
- Canada Research Chair program
- State Administration of Foreign Experts Affairs
- P.R. China
- Chinese Academy of Sciences
- Natural Science and Engineering Research Council of Canada [326415-07]
- Western Economic Diversification Canada [6578, 6807, 000012711]
- Canada Foundation for Infrastructure
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The synthetic flame retardant tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) has been frequently detected in natural waters, and its maximum concentration ever reported is 377 ng/L. However, information on the adverse effects of environmentally relevant concentrations of TDCIPP on aquatic organisms are totally unknown. In this study, <12-h old water fleas, D. magna, were exposed to concentrations of 0, 65 +/- 7.1, 550 +/- 33, or 6500 +/- 1400 ng/L TDCIPP, and dose- and time-dependent effects on reproduction and development were evaluated. Sequences of genes of D. magna were obtained from the National Center for Biotechnology Information and were used to develop PCR arrays for D. magna. Arrays were then used to study transcriptional responses of D. magna to TDCIPP. Exposure to environmentally relevant concentrations of TDCIPP significantly decreased fecundity as well as length of F-0 and F-1 generations. Transcriptional responses showed that, of the 155 genes tested, expressions of 57 genes were significantly changed, and some changes occurred following exposure to environmentally relevant concentrations (i.e., 65 +/- 7.1 and 550 +/- 23 ng/L). Furthermore, pathways related to protein synthesis and metabolism and endocytosis were considered to be significantly affected in a dose- and time-dependent manner and might be responsible for TDCIPP-induced reproductive and developmental toxicities.
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