Electrochemical transformations and anti/prooxidant activity of sterically hindered o-benzoquinones

The electrochemical properties of a series of sterically hindered o-benzoquinones in aprotic solvents were examined. The reaction of O-2 and KO2 with o-benzoquinones and electrogenerated o-semiquinone radical anions was studied. The formation of o-semiquinone radical anions in the reactions of KO2 with the studied o-quinones was detected using UV-visible and ESR spectroscopy. The influence of the test compounds on lipid peroxidation was considered at the molecular and tissue levels in vitro. In the most cases, o-quinones exhibit antioxidant activity, which varies depending on the type of lipid substrate.