Journal
BIOLOGICAL RHYTHM RESEARCH
Volume 49, Issue 1, Pages 39-49Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09291016.2017.1333193
Keywords
Tat; locomotor activity; melatonin; circadian rhythm; clock genes
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Funding
- National Natural Science Foundation of China [31371180]
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Transactivator (Tat), a regulatory protein of HIV-1, plays a very important role in HIV-1 infection by promoting the rapid replication of HIV. Research surrounding Tat protein function has mainly focused on inhibition of the immune system, promotion of growth of vascular endothelial cells, and nervous system damage. To date, very little research has addressed the role of Tat in circadian rhythms. Previous studies in our lab have found that the concentration of Tat protein in HIV patients' blood was positively correlated with patients' sleep quality and melatonin concentrations. In this study, we applied a Tat expression plasmid in mice. Result demonstrated that the locomotor activities of mice and the concentration of melatonin were significantly increased. Alternatively, the expression of Clock gene was markedly decreased. On the other hand, the expression of the Cry1 gene was significantly increased, while the expression of Bmal1 and Per1 genes exhibited no significant difference.
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