Journal
DEVELOPMENTAL NEUROBIOLOGY
Volume 78, Issue 3, Pages 283-297Publisher
WILEY
DOI: 10.1002/dneu.22534
Keywords
neuronal maintenance; membrane degradation; endosome; lysosome; autophagy
Categories
Funding
- Deutsche Forschungsgemeinschaft [SFB958, SFB/TRR186]
- National Institute of Health (Neuro-Cure Cluster Berlin) [RO1EY018884, RO1EY023333]
- Muscular Dystrophy Association of the USA
- NIH [T32 NS069562, F31 NS084774]
- DFG [SFB958]
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Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments. Both longevity and morphological complexity represent challenges for regulated membrane protein degradation. To investigate how neurons cope with these challenges, an increasing number of recent studies investigated local, cargo-specific protein sorting, and degradation at axon terminals and in dendritic processes. In this review, we explore the current answers to the ensuing questions of where, what, and when membrane proteins are degraded in neurons. (c) 2017 The Authors Developmental Neurobiology Published by Wiley Periodicals, Inc. Develop Neurobiol 78: 283-297, 2018
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