Journal
CELLULOSE
Volume 25, Issue 2, Pages 1229-1238Publisher
SPRINGER
DOI: 10.1007/s10570-017-1632-z
Keywords
Cellulose acetate; Gabapentin; Gelatin; Neural tissue engineering scaffold; Wet-electrospinning
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In the present study, gabapentin (GBP), an anticonvulsant drug used as an analgesic to control the neuropathic pains, was incorporated with cellulose acetate (CA) and gelatin (Gel) in order to develop a potential scaffold for neural tissue engineering applications. The wet-electrospinning method was used to produce the drug-loaded three-dimensional scaffolds from CA/Gel [1:1 (w/w)] solution in the water/ethanol (3:7) (v/v) coagulation baths containing 3%, 6% and 12% (w/v) of GBP. The scaffolds were evaluated regarding their morphology, contact angle, porosity, tensile strength and cellular response. The scaffold obtained from 6% (w/v) GBP bath was chosen as the optimum scaffold for further in vivo study in a sciatic nerve defect model in Wistar rats. The results of sciatic functional index, hot plate latency, weight-loss percentage of the wet gastrocnemius muscle and the histopathological examination using hematoxylin-eosin staining demonstrated that the GBP-containing scaffold significantly enhanced the regeneration of the created injury, which demonstrates its applicability for neural tissue engineering applications.
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