Journal
ALLERGY
Volume 73, Issue 3, Pages 696-704Publisher
WILEY
DOI: 10.1111/all.13320
Keywords
atopic dermatitis; atopic eczema; eczema; natural history; prevalence
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Funding
- National Institutes of Health National Center for Advancing Translational Sciences UCSF-CTSI [KL2 TR000143]
- Wellcome senior research fellowship in clinical science [205039/Z/16/Z]
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BackgroundThere are sparse and conflicting data regarding the long-term clinical course of atopic dermatitis (AD). Although often described as a childhood disease, newer population-based estimates suggest the prevalence of pediatric and adult disease may be similar. MethodsOur objective was to determine whether there is a decline in the prevalence of AD in population-based cohorts of patients followed longitudinally beyond childhood. We conducted a systematic review and meta-analysis including studies assessing AD prevalence across 3 or more points in time. The primary outcome was weighted overall risk difference (percentage decrease in AD prevalence). ResultsOf 2080 references reviewed, 7 studies with 13515 participants were included. Participants were assessed at 3-6 time points, ranging from age 3months to 26years. The percentage decrease in prevalence after age 12 was 1%, which was not significantly different from zero (95% confidence interval -2%-5%). Similar results were found with other age cut-offs. ConclusionThe prevalence of AD in longitudinal birth cohort studies is similar in childhood and adolescence/early adulthood.
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