Journal
RNA
Volume 23, Issue 6, Pages 860-865Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1261/rna.058271.116
Keywords
RNA editing; single cell; RNA-seq; transcriptome
Categories
Funding
- Flagship InterOmics project [PB05]
- Italian Ministero dell'Istruzione, University e Ricerca (MIUR): PRIN
- Consiglio Nazionale delle Ricerche: Flagship Project Epigen, Medicina Personalizzata and Aging Program
- Flagship InterOmics project
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While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimodally distributed and distinguish between major brain cell types, thus providing new insights into neuronal dynamics.
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