Journal
TROPICAL MEDICINE AND INFECTIOUS DISEASE
Volume 3, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/tropicalmed3010011
Keywords
scrub typhus; Orientia tsutsugamushi; Tsutsugamushi Triangle; endemic region
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Funding
- Global Emerging Infections Surveillance Section, a Division of the Armed Forces Health Surveillance Branch, Defense Health Agency, U.S. Department of Defense [A1402]
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Scrub typhus is the most important rickettsial disease in the world. Its previous endemic region was considered to be in Asia, Australia and islands in the Indian and Pacific Oceans; this area was referred to as the Tsutsugamushi Triangle. Accumulation of serological, molecular, genetic, and culture data have shown that not only is scrub typhus not limited to the Tsutsugamushi Triangle, but can be caused by orientiae other than Orientia tsutsugamushi. This review describes evidence currently available that will be instrumental to researchers, healthcare providers and medical leaders in developing new research projects, performing diagnosis, and preventing scrub typhus in locations not previously thought to be endemic.
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