Journal
RNA BIOLOGY
Volume 14, Issue 7, Pages 865-890Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2017.1306171
Keywords
3end processing; alternative cleavage and polyadenylation; gene expression
Categories
Funding
- BBSRC [BB/N001184/1]
- MRC
- BBSRC [BB/N001184/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/N001184/1] Funding Source: researchfish
- Medical Research Council [1352809] Funding Source: researchfish
Ask authors/readers for more resources
Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation of primary protein encoding transcripts into functional mRNAs that can be exported from the nucleus and translated in the cytoplasm. 3end processing is dependent on the assembly of a multiprotein processing complex on the pA signals that reside in the pre-mRNAs. Most eukaryotic genes have multiple pA signals, resulting in alternative cleavage and polyadenylation (APA), a widespread phenomenon that is important to establish cell state and cell type specific transcriptomes. Here, we review how pA sites are recognized and comprehensively summarize how APA is regulated and creates mRNA isoform profiles that are characteristic for cell types, tissues, cellular states and disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available