Journal
RNA BIOLOGY
Volume 14, Issue 7, Pages 820-826Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2017.1312227
Keywords
Nuclear RNA degradation; poly(A) tail; poly(A) binding proteins; RNA exosome; RNA exosome adaptors; the PAXT connection
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Funding
- ERC [339953]
- Danish National Research Council
- Lundbeck-Foundation
- Novo Nordisk-Foundation
- European Research Council (ERC) [339953] Funding Source: European Research Council (ERC)
- Novo Nordisk Fonden [NNF15OC0017010] Funding Source: researchfish
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Centrally positioned in nuclear RNA metabolism, the exosome deals with virtually all transcript types. This 3-5 exo- and endo-nucleolytic degradation machine is guided to its RNA targets by adaptor proteins that enable substrate recognition. Recently, the discovery of the Poly(A) tail exosome targeting (PAXT)' connection as an exosome adaptor to human nuclear polyadenylated transcripts has relighted the interest of poly(A) binding proteins (PABPs) in both RNA productive and destructive processes.
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