Journal
RNA BIOLOGY
Volume 14, Issue 8, Pages 978-984Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2017.1317911
Keywords
Back-splicing; circRNA; ectopic gene expression; RNA aptamers; tricRNA; tRNA processing
Categories
Funding
- National Scientific Foundation [DGE-1144081]
- National Institutes of Health [R01-GM118636]
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Circular (circ)RNAs have recently become a subject of great biologic interest. It is now clear that they represent a diverse and abundant class of RNAs with regulated expression and evolutionarily conserved functions. There are several mechanisms by which RNA circularization can occur in vivo. Here, we focus on the biogenesis of tRNA intronic circular RNAs (tricRNAs) in archaea and animals, and we detail their use as research tools for orthogonal, directed circRNA expression in vivo.
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