Journal
CURRENT OPINION IN BIOMEDICAL ENGINEERING
Volume 5, Issue -, Pages 90-95Publisher
ELSEVIER
DOI: 10.1016/j.cobme.2018.03.001
Keywords
Diffusion; Advection; Leukocytes; Chemotaxis; Lymphatics
Categories
Funding
- Royal Society [WM120065]
- Royal Academy of Engineering [10145/90]
- Sir Leon Bagrit Trust
- National Institutes of Health [U01-HL-123420]
- Wellcome Trust Collaborative Award [206284/Z/17/Z]
- U.K. Medical Research Council funds [N023625/1, M019764/1]
- MRC [MR/M019764/1, MR/N023625/1] Funding Source: UKRI
- Royal Society [WM120065] Funding Source: Royal Society
- Wellcome Trust [206284/Z/17/Z] Funding Source: Wellcome Trust
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Leukocyte migration is critically important during all protective and pathological immune and inflammatory responses. Chemokines play fundamental roles in this process, and chemokine concentration gradients stimulate the directional migration of leukocytes. The formation and regulation of these gradients is poorly understood. These are complex processes that depend on the specific properties of each chemokine and interactions between physical, biological and biochemical processes, including production, diffusion, advection, scavenging, post-translational modification, and extracellular matrix (ECM) binding. While some of these mechanisms have been investigated in isolation or limited combinations, more integrative research is required to provide a quantitative knowledge base that explains how chemokine gradients are established and maintained, and how cells respond to, and modify, these gradients.
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