Journal
TRENDS IN CANCER
Volume 4, Issue 3, Pages 176-196Publisher
CELL PRESS
DOI: 10.1016/j.trecan.2018.01.003
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Funding
- National Cancer Institute [2P30CA008748-48]
- Mundipharma
- Amgen
- German Cancer Aid (Deutsche Krebshilfe), Translational Oncology Program
- Prevent Brain Metastasis Consortium
- MINECO-Retos [SAF2014-57243-R]
- MINECO-Europa Excelencia [SAF2015-62547-ERC]
- IX FERO Grant for Research in Oncology
- Bristol-Myers Squibb Melanoma Research Alliance Young Investigator Award
- Beug Foundation Prize for Metastasis Research
- Ramon y Cajal Investigator [RYC-2013-13365]
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Metastasis, involving the spread of systemic cancer to the brain, results in neurologic disability and death. Current treatments are largely palliative in nature; improved therapeutic approaches represent an unmet clinical need. However, recent experimental and clinical advances challenge the bleak long-term outcome of this disease. Encompassing key recent findings in epidemiology, genetics, microenvironment, leptomeningeal disease, neurocognition, targeted therapy, immunotherapy, and prophylaxis, we review preclinical and clinical studies to provide a comprehensive picture of contemporary research and the management of secondary brain tumors.
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