Journal
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
Volume 43, Issue 3, Pages 489-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.rdc.2017.04.013
Keywords
Pregnancy; Corticosteroids; Adverse pregnancy and birth outcomes; Review
Categories
Funding
- National Institutes of Health (NIH) [TL1TR001443]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health [K99HD082412]
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The evidence to date regarding corticosteroid exposure in pregnancy and select pregnancy and birth outcomes is limited and inconsistent. The authors provide a narrative review of published literature summarizing the findings for oral clefts, preterm birth, birth weight, preeclampsia, and gestational diabetes mellitus. Whenever possible, the results are limited to oral or systemic administration with a further focus on use in autoimmune disease. Although previous studies of corticosteroid exposure in pregnancy reported an increased risk of oral clefts in the offspring, more recent studies have not replicated these findings.
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